MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23. This was the largest series of gynecological malignancies investigated for carboplatin-related hypersensitivity reactions. We analyzed the incidence, characteristics, risk factors, management, and outcomes of carboplatin-related hypersensitivity reactions among these patients. doi: 10.1016/j.ygyno.2007.06.016, Markman, M., Kennedy, A., Webster, K., Elson, P., Peterson, G., Kulp, B., et al. doi: 10.1111/cas.12538, Kandel, M. J., Loehr, A., Harter, P., Traut, A., Gnauert, K., and du Bois, A. The characteristics of the 735 patients are presented in Table 2. The research protocol was reviewed and approved by the institutional review board of the hospital. Study conception and design: Y-HT and W-FC. -. Leuk Lymphoma. Symptoms and signs of 75 patients with hypersensitivity reactions to carboplatin. These scores have been defined by the guideline authors and validated by the ESMO Translational Research and Precision Medicine Working Group.17 g Selpercatinib is EMA approved for treating adults with advanced or metastatic RET fusion-positive TC who had already received lenvatinib or sorafenib. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The yearly incidence of carboplatin-related hypersensitivity gradually increased from 0.88 in 2006 to 5.42% in 2013 (Table 1), in association with increased use of carboplatin. Genc et al. (Markman, 2007) reported that carboplatin-related hypersensitivity reactions rarely occur before cycle 6 or <3,000 mg of drug delivery, with the first episode most commonly occurring with carboplatin administration in the second-line setting, and carboplatin administration beyond 9 cycles or 6,000 mg increasing the risk of severe hypersensitivity reactions, similar to our present observations. Here's a summary of the new ESMO guidelines in 5 key areas: . Abe, A., Ikawa, H., and Ikawa, S. (2010). An official website of the United States government. Have a look to the ESMO 2017 Programme online! J. Gynecol. 105, 14721479. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2019 Sep;60(9):2295-2298. doi: 10.1080/10428194.2019.1576871. Report of three cases. Oncol Res Treat. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. This review provides insight into the current knowledge of drug allergy and anaphylaxis to cancer and chronic inflammatory diseases drugs, the mechanisms of drug desensitization and its applications to personalized medicine. Similarly, Kandel et al. Summary format including algorithms, figures andtables for your presentations. Utilizing Biologics in Drug Desensitization. Nektaria M, Ekaterini S, Ioannis K, Leonidas M, Muhammad Wasif S. Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review. Bayer to Highlight New Research at ESMO 2017 Congress - PR Newswire Oncol. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. . Annals of Oncology (2021) 32 (suppl_5): S407-S446. For more detailed information on the cookies we use, please check our Privacy Policy. Unauthorized use of these marks is strictly prohibited.
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